2020-8-9 · Prostatic Neoplasms Ovarian Neoplasms Breast Neoplasms Lung Neoplasms Stomach Neoplasms Colonic Neoplasms Neoplasm Metastasis Neoplasm Invasiveness Pancreatic Neoplasms Neoplasms Uterine Cervical Neoplasms Genetic Predisposition to Disease Carcinoma Urinary Bladder Neoplasms Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Disease
INTRODUCTION. Surgery is the most common intervention in oncology, but the resultant wound healing process can promote metastasis (), which accounts for 90% of cancer-related deaths ().Recurrence of primary tumors after surgery is associated with poor outcomes, increased local immunosuppression, and distant metastasis ().A set of genes that mediate breast cancer metastasis to lung has been
Maruyama et al. provide evidence from mouse experiments that fecal single-stranded RNA (ssRNA) is sensed in the gut by the ion channel Piezo1. They show that ssRNA-stimulated Piezo1 is involved in peristalsis and gut serotonin synthesis and reduced bone mass. The ssRNA-Piezo1 axis reported could be a prophylactic target for treatment of bone and gut disorders, including the side effects of
MD2 inhibitor suppresses CT26.WT lung metastasis in BALB/c mice. Our findings indied that L6H21 was a selective and potent MD2 inhibitor in abrogating colon cancer cell activities. Therefore, we tested the inhibitory effectiveness of L6H21 in a mouse model of colon cancer cell metastasis to lungs.
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2019-12-12 · Rho GDP dissociation inhibitor 2 (RhoGDI2) was initially identified as a regulator of the Rho family of GTPases. Our recent works suggest that RhoGDI2 promotes tumor growth and malignant progression, as well as enhances chemoresistance in gastric cancer. Here, we delineate the mechanism by which RhoGDI2 promotes gastric cancer cell invasion and chemoresistance using two-dimensional …
Calcium ions (Ca 2+) serve as the universal signal to modulate various aspects of cellular functions in keratinocytes.The distribution and dynamic of Ca 2+ in skin play an important role in epidermal homeostasis. In mammalian epidermis, a characteristic calcium gradient exists between lower and upper layers of epidermis, with low levels in basal and spinous layers and progressively increasing
Aberrant lncRNA expression is responsible for cancer progression and metastasis, positioning lncRNAs not only as biomarkers but also as promising therapeutic targets for curing cancer. A nuer of lncRNAs have been reported in ESCC but their mechanistic roles largely remain unknown. Wnt signaling pathways are often dysregulated in ESCC; however, the role of lncRNAs in such dysregulation was
Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor. J Biol Chem 267: 19876-19883.
2019-8-14 · Introduction. Gynecologic malignancies include cervical cancer, endometrial cancer, and ovarian cancer. Ovarian cancer is the second most common gynecologic malignancy (, 1); however, it remains the leading cause of death among these diseases and is the fourth leading cause of cancer deaths in women in the United States (, 1).In spite of diagnostic and therapeutic advances in the care …
Metastasis is a complex multistep process, during which tumor cells spread from the primary tumor mass to distant organs. Recent evidence indies Twist plays a key role in the metastasis of breast cancer, by promoting epithelial-to-mesenchymal transition.
(A) Genomic organization of pyp‐1 gene in C. elegans .Genetic and physical maps of the pyp‐1 region. The pyp‐1 locus relative to the nearby genetic markers on the gene cluster region of LG IV is shown. The pyp‐1 is mapped to the cosmid C47E12. The C47E12.4 gene (pyp‐1 ) as predicted by Worase has four isoforms (C47E12.4a‐d).(B) Amino acid sequence alignment of PYP‐1.
2 · Melanoma is a cancer that has a high mortality rate in the absence of targeted therapy. Conventional therapies such as surgery, chemotherapy, and radiotherapy are associated with poor prognosis. The expression of miR-21 appears to be of clinical importance, and the regulation of its expression appears to be an opportunity for treatment. In this current study, we aimed to evaluate the …
2020-8-4 · beta-enin antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), chImmunoprecipitation (IP), Enzyme-linked Immunosorbent Assay (ELISA) appliions. This antibody reacts with human, mouse, rat, pig samples. .No. 51067-2-AP. KD/KO Validated.
Review Article. June 23, 2020. Encountering COVID-19 as Endocrinologists Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, et al. Endocrinol Metab. 2020;35(2):197-205.
Pain may be induced by activation of various ion channels expressed in primary afferent neurons. These channels function as molecular sensors that detect noxious chemical, temperature, or tactile stimuli and transduce them into nociceptor electrical signals. Transient receptor potential channels are good examples because they are activated by chemicals, heat, cold, and acid in nociceptors.
2019-1-3 · Then, the zirconia particles were retrieved by a sieve (Daehan Science; Seoul, Korea) with 425 μm pores. The mixture of dicalcium phosphate and calcium carbonate in powder was transferred to an aluminum tray and ethanol was removed by keeping it in a heating oven at 70 °C for 24 h.
NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response. - Mechanism of Action & Protocol.
2020-7-31 · The report entitled Global Dibasic Calcium Phosphate Market 2020 by Manufacturers, Type and Appliion, Forecast to 2025 compiled by MarketsandResearch includes an elemental introduction to the industry, market overview, scope, and product specifiion. The report aims to target the major images related to market growth, major types, and various end users applicable, regional …
Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implied in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis.
2020-6-28 · HemoHIM, is a Korean functional health food supplement developed through biotechnology and radiation technologies from the food-life engineering team of the Korea Atomic Energy Research Institute (KAERI). It was a government project supported by the Ministry of Science and Technology, Korea, which spanned for 8 years, costing them 5 billion won (roughly USD $4.7 million).…
Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism Jung Soo Lim, Namki Hong, Sungha Park et al. Endocrinol Metab. 2018;33(4):485-492. …
2020-7-7 · This work presents a concept for promoting the neuronal regenerative potential by engineering the expression of a stem cell marker, Prom1 . We identify Prom1 as a developmentally down-regulated neuronal intrinsic factor of axon regeneration. Replenishing Prom1 expression amplifies the axonal regenerative potential by transcriptionally inhibiting cholesterol metabolism via Smad-dependent …
Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res. 2010 Feb 1;70(3):1173-83. The Direct Effect of Levobupivacaine in Isolated Rat Aorta Involves Lipoxygenase Pathway Activation and Endothelial Nitric Oxide Release.
Concurrently, PLC hydrolyzes PIP2 to produce inositol-triphosphate (IP3) and diacylglycerol (DAG), which trigger calcium mobilization and Protein kinase C (PKC) activation, respectively. Activation of PKC results in the phosphorylation of IKK, which then phosphorylates I kappa B, promoting its ubiquitin-dependent proteasomal degradation, and allowing NF-kappa B to transloe to the nucleus